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Recent data on the variable toxicity of different types of oligomers of the same peptide/protein grown at different conditions, and, hence, with different biophysical features (stability, compactness, hydrophobic exposure), further underscore that oligomer cytotoxicity is strictly dependent on the aggregation conditions and the cell membrane features [106,123]

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326 Approximately 65% of patients achieved serum uric acid levels less than 6.0 mg/dL, although concerns have been raised regarding the cardiac safety profile of febuxostat

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